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TSPO ligand-1

CAS No. 4560-08-1

TSPO ligand-1( —— )

Catalog No. M36556 CAS No. 4560-08-1

TSPO ligand-1 has affinity for peripheral and central benzodiazepine receptors.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    TSPO ligand-1
  • Note
    Research use only, not for human use.
  • Brief Description
    TSPO ligand-1 has affinity for peripheral and central benzodiazepine receptors.
  • Description
    TSPO ligand-1 is the ligand of AUTAC4 (HY-134640) that can be used in the synthesis of PROTACs. TSPO ligand-1 is a mitochondrial outer membrane transmembrane structural domain protein can bind to AUTAC4 and regulate mitochondrial autophagy to promote targeted mitochondrial renewal. TSPO ligand-1 is also involved in the transport of cholesterol from the outer to inner mitochondrial membrane and serves as a sensitive biomarker of brain injury and neurodegeneration.
  • In Vitro
    TSPO ligand-1 gene is induced to increase expression in the context of selective activation of neurons in male C57Bl6/N mice. Moreover, neuronal activation under physiological and psychopharmacological conditions also results in increased TSPO levels in adult mice.TSPO ligand-1 can serve as the sole marker of glial cell activity in Alzheimer’s disease thus tracking the formation of different neural cells.TSPO ligand-1 can regulate mitochondrial fatty acid oxidation (FAO) and thus effects mitochondrial energy homeostasis in MA-10 Leydig cell line.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Autophagy
  • Target
    Autophagy
  • Recptor
    Autophagy | Ligands for Target Protein for PROTAC
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    4560-08-1
  • Formula Weight
    283.71
  • Molecular Formula
    C16H10ClNO2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (440.59 mM; Ultrasonic )
  • SMILES
    O=C(Cl)C(=O)C=1C=2C=CC=CC2NC1C=3C=CC=CC3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Takahashi D, et, al. AUTACs: Cargo-Specific Degraders Using Selective Autophagy. Mol Cell. 2019 Dec 5;76(5):797-810.e10.?
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