
TSPO ligand-1
CAS No. 4560-08-1
TSPO ligand-1( —— )
Catalog No. M36556 CAS No. 4560-08-1
TSPO ligand-1 has affinity for peripheral and central benzodiazepine receptors.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
2MG | 47 | Get Quote |
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5MG | 67 | Get Quote |
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10MG | 112 | Get Quote |
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25MG | 218 | Get Quote |
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50MG | 327 | Get Quote |
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100MG | 480 | Get Quote |
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500MG | 1017 | Get Quote |
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1G | Get Quote | Get Quote |
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Biological Information
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Product NameTSPO ligand-1
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NoteResearch use only, not for human use.
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Brief DescriptionTSPO ligand-1 has affinity for peripheral and central benzodiazepine receptors.
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DescriptionTSPO ligand-1 is the ligand of AUTAC4 (HY-134640) that can be used in the synthesis of PROTACs. TSPO ligand-1 is a mitochondrial outer membrane transmembrane structural domain protein can bind to AUTAC4 and regulate mitochondrial autophagy to promote targeted mitochondrial renewal. TSPO ligand-1 is also involved in the transport of cholesterol from the outer to inner mitochondrial membrane and serves as a sensitive biomarker of brain injury and neurodegeneration.
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In VitroTSPO ligand-1 gene is induced to increase expression in the context of selective activation of neurons in male C57Bl6/N mice. Moreover, neuronal activation under physiological and psychopharmacological conditions also results in increased TSPO levels in adult mice.TSPO ligand-1 can serve as the sole marker of glial cell activity in Alzheimer’s disease thus tracking the formation of different neural cells.TSPO ligand-1 can regulate mitochondrial fatty acid oxidation (FAO) and thus effects mitochondrial energy homeostasis in MA-10 Leydig cell line.
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In Vivo——
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Synonyms——
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PathwayAutophagy
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TargetAutophagy
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RecptorAutophagy | Ligands for Target Protein for PROTAC
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Research Area——
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Indication——
Chemical Information
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CAS Number4560-08-1
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Formula Weight283.71
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Molecular FormulaC16H10ClNO2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 125 mg/mL (440.59 mM; Ultrasonic )
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SMILESO=C(Cl)C(=O)C=1C=2C=CC=CC2NC1C=3C=CC=CC3
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Takahashi D, et, al. AUTACs: Cargo-Specific Degraders Using Selective Autophagy. Mol Cell. 2019 Dec 5;76(5):797-810.e10.?
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