
TSPO ligand-1
CAS No. 4560-08-1
TSPO ligand-1( —— )
Catalog No. M36556 CAS No. 4560-08-1
TSPO ligand-1 has affinity for peripheral and central benzodiazepine receptors.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
2MG | 47 | Get Quote |
![]() ![]() |
5MG | 67 | Get Quote |
![]() ![]() |
10MG | 112 | Get Quote |
![]() ![]() |
25MG | 218 | Get Quote |
![]() ![]() |
50MG | 327 | Get Quote |
![]() ![]() |
100MG | 480 | Get Quote |
![]() ![]() |
500MG | 1017 | Get Quote |
![]() ![]() |
1G | Get Quote | Get Quote |
![]() ![]() |
Biological Information
-
Product NameTSPO ligand-1
-
NoteResearch use only, not for human use.
-
Brief DescriptionTSPO ligand-1 has affinity for peripheral and central benzodiazepine receptors.
-
DescriptionTSPO ligand-1 is the ligand of AUTAC4 (HY-134640) that can be used in the synthesis of PROTACs. TSPO ligand-1 is a mitochondrial outer membrane transmembrane structural domain protein can bind to AUTAC4 and regulate mitochondrial autophagy to promote targeted mitochondrial renewal. TSPO ligand-1 is also involved in the transport of cholesterol from the outer to inner mitochondrial membrane and serves as a sensitive biomarker of brain injury and neurodegeneration.
-
In VitroTSPO ligand-1 gene is induced to increase expression in the context of selective activation of neurons in male C57Bl6/N mice. Moreover, neuronal activation under physiological and psychopharmacological conditions also results in increased TSPO levels in adult mice.TSPO ligand-1 can serve as the sole marker of glial cell activity in Alzheimer’s disease thus tracking the formation of different neural cells.TSPO ligand-1 can regulate mitochondrial fatty acid oxidation (FAO) and thus effects mitochondrial energy homeostasis in MA-10 Leydig cell line.
-
In Vivo——
-
Synonyms——
-
PathwayAutophagy
-
TargetAutophagy
-
RecptorAutophagy | Ligands for Target Protein for PROTAC
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number4560-08-1
-
Formula Weight283.71
-
Molecular FormulaC16H10ClNO2
-
Purity>98% (HPLC)
-
SolubilityIn Vitro:?DMSO : 125 mg/mL (440.59 mM; Ultrasonic )
-
SMILESO=C(Cl)C(=O)C=1C=2C=CC=CC2NC1C=3C=CC=CC3
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Takahashi D, et, al. AUTACs: Cargo-Specific Degraders Using Selective Autophagy. Mol Cell. 2019 Dec 5;76(5):797-810.e10.?
molnova catalog



related products
-
ULK1-IN-2
ULK1-IN-2 is a potent ULK1 inhibitor with potential anticancer activity, inducing apoptosis while blocking autophagy.
-
Sulfalen
Sulfalene is a long-acting sulfonamide antibiotic used for the treatment of chronic bronchitis, urinary tract infections and malaria.
-
rel-(8R,8'R)-dimethy...
rel-(8R,8'R)-Dimethyl-(7S,7'R)-bis(3,4-methylenedioxyphenyl)tetrahydro-furan is a chemical constituent of the fruit of Myristica fragrans.