TSPO ligand-1

CAS No. 4560-08-1

TSPO ligand-1( —— )

Catalog No. M36556 CAS No. 4560-08-1

TSPO ligand-1 has affinity for peripheral and central benzodiazepine receptors.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 47 Get Quote
5MG 67 Get Quote
10MG 112 Get Quote
25MG 218 Get Quote
50MG 327 Get Quote
100MG 480 Get Quote
500MG 1017 Get Quote
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Biological Information

  • Product Name
    TSPO ligand-1
  • Note
    Research use only, not for human use.
  • Brief Description
    TSPO ligand-1 has affinity for peripheral and central benzodiazepine receptors.
  • Description
    TSPO ligand-1 is the ligand of AUTAC4 (HY-134640) that can be used in the synthesis of PROTACs. TSPO ligand-1 is a mitochondrial outer membrane transmembrane structural domain protein can bind to AUTAC4 and regulate mitochondrial autophagy to promote targeted mitochondrial renewal. TSPO ligand-1 is also involved in the transport of cholesterol from the outer to inner mitochondrial membrane and serves as a sensitive biomarker of brain injury and neurodegeneration.
  • In Vitro
    TSPO ligand-1 gene is induced to increase expression in the context of selective activation of neurons in male C57Bl6/N mice. Moreover, neuronal activation under physiological and psychopharmacological conditions also results in increased TSPO levels in adult mice.TSPO ligand-1 can serve as the sole marker of glial cell activity in Alzheimer’s disease thus tracking the formation of different neural cells.TSPO ligand-1 can regulate mitochondrial fatty acid oxidation (FAO) and thus effects mitochondrial energy homeostasis in MA-10 Leydig cell line.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Autophagy
  • Target
    Autophagy
  • Recptor
    Autophagy | Ligands for Target Protein for PROTAC
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    4560-08-1
  • Formula Weight
    283.71
  • Molecular Formula
    C16H10ClNO2
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 125 mg/mL (440.59 mM; Ultrasonic )
  • SMILES
    O=C(Cl)C(=O)C=1C=2C=CC=CC2NC1C=3C=CC=CC3
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Takahashi D, et, al. AUTACs: Cargo-Specific Degraders Using Selective Autophagy. Mol Cell. 2019 Dec 5;76(5):797-810.e10.?
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